What We're Exploring

This project explores the potential of natural bacterial defence systems as powerful tools for bioprotection. Just as CRISPR transformed genetics, other defence systems hidden within microbes could offer new ways to control pests and pathogens in Aotearoa.

By combining bioinformatics and lab-based methods, the team is identifying defence systems that can target harmful microbes or be used in precision biocontrol strategies. Aotearoa’s unique microbial diversity is a promising source of new tools.

What We're Learning

The team aimed to harness natural defence systems in the bioprotection battle. For example, we developed CRISPR-based genetic tools for gene knockdowns across kingdoms, established proof-of-concept molecular detection systems based on CRISPR-Cas systems, and screened a microbial collection for new defence systems, discovering phage-like tailocin elements that specifically kill bacterial pathogens of potato. All of the new systems and components we have characterised may provide future tools with biotechnological utility.

Research Projects

Completed

T1 | Harnessing Biodefences

Fighting crop pathogens with viruses

Project Team

Prof Peter Fineran

Prof Peter Fineran

Roles:

Research Co-Lead

Institution:

University of Otago

Assoc Prof Paul Gardner

Assoc Prof Paul Gardner

Roles:

Researcher

Institution:

University of Otago

Dr Simon Jackson

Dr Simon Jackson

Roles:

Researcher

Institution:

University of Waikato

Dr Rob Fagerlund

Dr Rob Fagerlund

Roles:

Researcher

Institution:

University of Otago

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